Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

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Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

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Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

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Pure CBD Lotion

Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

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A Word About Health Claims and CBD

and Health CBD Physical

stemt01
04.06.2018

Content:

  • and Health CBD Physical
  • Everything you need to know about CBD oil
  • What is CBD oil?
  • Scientists studying the health benefits of CBD have found it is a promising natural that could connect brain activity and states of physical health and disease. Cannabidiol, or CBD, is a chemical compound in marijuana with a variety of Here are seven health benefits of CBD oil that are backed by. Cannabidiol (CBD) may have some health benefits, and it may also . of CBD oil might complement a medical approach to treating physical.

    and Health CBD Physical

    Scientists measured the anxiety-reducing effects of CBD in a group of 57 healthy male volunteers by having them undergo one of the most universally stress-provoking activities: The simulated public speaking test is actually one common way scientists investigate anxiety and methods to treat it.

    The study found CBD worked effectively to decrease anxiety. The scientists tested different doses , , and mg and found the middle-range dose had the largest effect on lowering stress and anxiety. This study aligns with previous research showing CBD was able to reduce anxiety before public speaking in both people with generalized anxiety and people without this anxiety condition.

    Another study released in —this one conducted in rats—found CBD worked to lower both pain and anxiety simultaneously. Stress, anxiety and physical pain are some of the most common obstacles to healthy, restful, plentiful sleep. Brand new research has found that regular dosing of CBD may be necessary to get the benefits of this natural compound.

    Like other research, they found CBD relieved pain and reduced anxiety symptoms , and increased serotonin in the brain. When examining frequency of dosing, the scientists found a single, one-time dose of CBD did not improve pain or anxiety. Rather, people needed to use CBD for at least a week to see improvement. These study results suggest that routine use of CBD may be the way to get the best results from this cannabinoid.

    People today often use CBD to improve their cognitive performance, including their mental clarity, focus and concentration. We saw more research this year that added to this accumulating body of evidence.

    Scientists found CBD may protect the brain against the negative effects of excessive iron accumulation. Iron collects in the brain as part of the normal aging process. CBD has well-identified abilities as an anti-inflammatory and antioxidant in the human body. CBD is being intensely investigated for its potential as a treatment for some cancers. Previous studies have shown CBD may inhibit cancer cell growth and metastasis in several different types of cancer, including forms of breast, colon, lung and brain cancers.

    In , UK scientists released the results of a study in which they examined the effects of CBD on cancerous cells. They found that CBD can reduce growth of some types of cancer cells by limiting the release of tiny structures that protect and aid the growth of cancer cells.

    CBD, they found, also may make cancer cells more sensitive to chemotherapy. New information about CBD dosing Brand new research has found that regular dosing of CBD may be necessary to get the benefits of this natural compound.

    Can CBD protect against age-related damage to the brain? CBD as a cancer fighter? Sweet Dreams, Michael J. However, both capsaicin VR1 agonist and CP55, an CB1 agonist had antihyperkinetic activity Quinolinic acid QA is an excitotoxin which, when injected into the rat striatum, reproduces many features of HD by stimulating glutamate outflow. Perfusion with WIN 55, significantly and dose-dependently prevented the increase in extracellular glutamate induced by QA.

    Thus, the stimulation of CB1 receptors might lead to neuroprotective effects against excitotoxic striatal toxicity. Tourette syndrome TS is a complex inherited disorder of unknown etiology, characterized by multiple motor and vocal tics. Anecdotal reports have suggested that the use of cannabis might improve tics and behavioral problems in patients with TS.

    There was a significant improvement of motor tics, vocal tics and obsessive-compulsive behavior after treatment with THC. Amyotrophic lateral sclerosis ALS is a fatal neurodegenerative disorder characterized by a selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Many effects of marijuana may be applicable to the management of ALS. These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction.

    In addition, its strong antioxidative and neuroprotective effects may prolong neuronal cell survival. Furthermore, genetic ablation of the FAAH enzyme, which results in raised levels of the endocannabinoid anandamide, prevented the appearance of disease signs in these mice. Ablation of the CB1 receptor, in contrast, had no effect on disease onset in these mice, but significantly extended life span.

    Together these results show that cannabinoids have significant neuroprotective effects in this model of ALS, and suggest that these beneficial effects may be mediated by nonCB1 receptor mechanisms. Administration at the onset of tremors delayed motor impairment in treated mice when compared with vehicle controls ; moreover, AM prolonged survival in these mice.

    Studies on cannabinoid anticonvulsant activity began in , when CBD, and four CBD derivatives, CBD-aldehyde-diacetate, 6-oxo-CBD-diacetate, 6-hydroxy-CBD-tri-acetate and 9-hydroxy-CBD-triacetate were shown to protect against maximal electroshock convulsions in mice, to potentiate pentobarbital sleeping-time and to reduce spontaneous motor activity. Furthermore, it appears that CBD enhances the anticonvulsant effects of drugs in major seizures and reduces their effects in minor seizures.

    The induction of status epilepticus-like activity by CB1 receptor antagonists was reversible and could be overcome by maximal concentrations of CB1 agonists. Cannabis use is common in patients with bipolar disorder, and anecdotal reports suggest that some patients use marijuana to alleviate symptoms of both mania and depression. The effect of cannabinoids on schizophrenia is controversial.

    Neuropsychological results in THC-intoxicated normal volunteers exhibit strong similarities with data acquired from patients suffering from productive schizophrenic psychoses, as regards disturbances in internal regulation of perceptual processes. Data from experimental-psychological tests show that personality changes generated by schizophrenia progression are comparable to psychopathological phenomenon due to cannabis intoxication.

    This argues against a distinct schizophrenia-like psychosis caused by cannabis. The group receiving the CB1 antagonist did not differ from the group receiving placebo on any outcome measure. CBD causes antipsychotic effects.

    Posttraumatic stress disorder PTSD is a term for severe psychological consequences of exposure to, or confrontation with, stressful, highly traumatic events. Cannabinoids are believed to help in such cases. AMtreated animals showed decreased shock-induced reinstatement of fear.

    SRI blocked the effects of OL, suggesting that endogenous anandamide plays a facilitator role in extinction through a CB1 receptor mechanism of action.

    However, upon repeated stress or acute severe stress, CB1 receptor deficiency causes persistent behavioral inhibition. Repeated bell stress seemed to cause a cumulative fear in CB1 receptor knockout mice. CB1 receptor gene polymorphism is known to modify transcription of the gene. In patients with Parkinson's disease, the presence of two long alleles, with more than 16 repeated AAT trinucleotides in the CNR1 gene, was associated with a reduced prevalence of depression.

    CBD, and some derivatives, were found to cause a selective anxiolytic effect in the elevated plus-maze, within a limited range of doses. The effects of marijuana on human sleep patterns were noticed long ago. Asthma is a chronic disease of the respiratory system in which the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus. In animal experiments, after methacholine-induced or exercise-induced bronchospasm, marijuana caused a prompt improvement of the bronchospasm and associated hyperinflation.

    The daily use of THC was not associated with clinical tolerance. Maximal bronchodilatation was achieved more rapidly with salbutamol, but at 1 hour both drugs were equally effective.

    No cardiovascular or mood disturbance was detected, and plasma total cannabinoids at 15 minutes were not detected by radioimmunoassay. The mode of action of THC differed from that of sympathomimetic drugs.

    In another study, THC induced sympathetic stimulation and parasympathetic inhibition of cardiovascular control pathways. The peak heart rate rise after THC was attenuated by atropine and by propranolol, and nearly abolished by atropine-propranolol pretreatment.

    With repetitive dosing supine bradycardia and decreased blood pressure with tolerance to orthostatic hypotension were observed. A number of studies suggest that there is a correlative, but not necessarily causal, relationship between glaucoma and systemic hypertension. Ocular hypertension OHT refers to any situation in which intraocular pressure is higher than normal, and is the most important risk factor for glaucoma.

    In contrast, noladin ether decreased IOP immediately after topical administration, and no initial IOP increase was observed. CB2 mRNA was undetectable. Ocular toxicity was seen after THC treatment, consisting of conjunctival erythema and chemosis as well as corneal opacification. Although these changes also occurred with marijuana extract, their intensity was much reduced. In contrast, no ocular toxicity was apparent during administration of plant cannabinoids other than THC.

    The results indicate that THC may have value as a hypotonizing ocular drug. The intensity and duration of the arterial and ocular pressure responses to THC were greater in hypertensives than in normotensive patients; the changes in ocular pressure paralleled the changes in blood pressure in glaucoma patients.

    The antiproliferative action of cannabinoids on cancer cells was first noticed in the s. Since then cannabinoids were found to act on various cancer cell lines, through various mechanisms. Moreover, cannabinoid challenge decreased the efficiency of glioma stem-like cells to initiate glioma formation in vivo.

    Activation of these receptors decreased growth, proliferation, angiogenesis, and metastasis, and increased apoptosis, of melanomas in mice. These effects were prevented by blockade of the CB2 cannabinoid receptor or by pharmacologic inhibition of ceramide synthesis de novo.

    THC inhibited tumor-cell proliferation in vitro, decreased tumor-cell Ki67 immunostaining and prolonged the survival time of two of the patients. Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others.

    Nevertheless they are still an important part of our pharmacopeia. Marijuana was used for centuries as a medicinal plant, but during the last century, because of its abuse and addictive potential it was taken out of clinical practice. Now, we believe that its constituents and related compounds should be brought back to clinical use. The endocannabinoid system is a very complex one and regulates numerous processes, in parallel with other wellknown systems, such as the adrenergic, cholinergic, and dopaminergic systems.

    National Center for Biotechnology Information , U. Journal List Dialogues Clin Neurosci v. Kogan , MSc Natalya M. Author information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution License http: This article has been cited by other articles in PMC. Abstract Cannabis sativa L. Abstract Las preparaciones de Cannabis sativa L. Addiction to canabis, and the influence of cannabis on addiction to other substances Marijuana may produce mild dependence in humans.

    Negative effects of cannabis other than addiction There are some negative effects of cannabis use other than addiction, most of them related to alterations of attentional and cognitive functions or other neuropsychological and behavioral effects.

    Therapeutic uses of cannabinoids Obesity, anorexia, emesis Cannabis has been known for centuries to increase appetite and food consumption. Pain Cannabis has been used for millennia as a pain-relieving substance. Multiple sclerosis, neuroprotection, inflammation Inflammation, autoimmune response, demyelination, and axonal damage are thought to participate in the pathogenesis of MS.

    Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease, epilepsy Parkinson's disease PD is a chronic, progressive neurodegenerative disorder. Bipolar disorder, schizophrenia, post-traumatic stress disorder PTSD , depression, anxiety, insomnia Cannabis use is common in patients with bipolar disorder, and anecdotal reports suggest that some patients use marijuana to alleviate symptoms of both mania and depression.

    Asthma, cardiovascular disorders, glaucoma Asthma is a chronic disease of the respiratory system in which the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus.

    Cancer The antiproliferative action of cannabinoids on cancer cells was first noticed in the s. Conclusion Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others.

    Early medical use of cannabis. Untersuchung der Cannabis sativa. Repertorium fur die Pharmacie. Note sur le haschisch. A historical overview of chemical research on cannabinoids. Isolation, structure and partial synthesis of the active constituent of hashish.

    J Am Chem Soc. Marihuana, an annotated bibliography. Withdrawal symptoms in cannabis indica addicts. The addictive potential of cannabis. Clinical studies of cannabis tolerance and dependence. Ann N Y Acad Sci. Treatment of cannabis use disorders: Cannabis addiction and Telic Dominance Scale. Clinical trial of abstinencebased vouchers and cognitive-behavioral therapy for cannabis dependence. J Consult Clin Psychol.

    Addictive potential of cannabinoids: Failure of Delta 9 -tetrahydrocannabinol and CP 55, to maintain intravenous self-administration under a fixed-interval schedule in rhesus monkeys. Endocannabinoid system and alcohol addiction: Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.

    SR, a central cannabinoid CB 1 receptor antagonist, blocks the motivational and dopaminereleasing effects of nicotine in rats. The diagnosis of alcohol and cannabis dependence addiction in cocaine dependence addiction. Behavioral effects of cocaine alone and in combination with ethanol or marijuana in humans.

    Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers. Involvement of cannabinoid CB1 receptors in drug addiction: Rimonabant, a CB1 antagonist, blocks nicotineconditioned place preferences. Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: The role of the cannabinoid system in nicotine addiction.

    Successful control of lipids, kilos and cigarettes]. Advances in pharmacotherapy for tobacco dependence. Expert Opin Emerg Drugs. Expert Opin Investig Drugs.

    Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats.

    Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: Cell Mol Life Sci.

    Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther. Cognitive functioning of longterm heavy cannabis users seeking treatment. Chronic cognitive impairment in users of 'ecstasy' and cannabis.

    Cannabis use, cognitive performance and mood in a sample of workers. Long-term effects of frequent cannabis use on working memory and attention: Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function.

    Cannabis, the mind and society: Cannabis and cognitive dysfunction: The psychotomimetic effects of intravenous deItatetrahydrocannabinol in healthy individuals: Amotivational syndrome in organic solvent abusers. Characteristics of abnormal behavior induced by delta 9-tetrahydrocannabinol in rats. Psychiatric aspects of cannabis use in adolescents and young adults.

    Related, induced and associated psychiatric disorders to cannabis. Operant acquisition of marihuana in man. Cannabis, motivation, and life satisfaction in an internet sample. Subst Abuse Treat Prev Policy.

    Endocannabinoids in the regulation of appetite and body weight. Endocannabinoids in appetite control and the treatment of obesity. Genetic variations at the endocannabinoid type 1 receptor gene CNR1 are associated with obesity phenotypes in men. J Clin Endocrinol Metab. Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.

    The role of CB1 receptors in sweet versus fat reinforcement: SR , a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors.

    Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: Clinical trials update and cumulative meta-analyses from the American College of Cardiology: Eur J Heart Fail.

    Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: Rimonabant in obese patients with type 2 diabetes. Am J Health Syst Pharm.

    Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. J Pain Symptom Manage. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.

    Dronabinol effects on weight in patients with HIV infection. The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. Cannabinoids in the treatment of the cachexiaanorexia syndrome in palliative care patients. A phase II study of deltatetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Mechanism of action of cannabinoids: An efficient new cannabinoid antiemetic in pediatric oncology.

    Cannabinoids for control of chemotherapy induced nausea and vomiting: Therapeutic potential of cannabinoids in trigeminal neuralgia. Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients.

    Int J Clin Pharmacol Res. Are oral cannabinoids safe and effective in refractory neuropathic pain? Lack of analgesic efficacy of oral deItatetrahydrocannabinol in postoperative pain.

    Pain relief with oral cannabinoids in familial Mediterranean fever. Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: Does the cannabinoid dronabinol reduce central pain in multiple sclerosis?

    Randomised double blind placebo controlled crossover trial. Effect of the synthetic cannabinoid dronabinol on central pain in patients with multiple sclerosis - secondary publication.

    The analgesic properties of deItatetrahydrocannabinol and codeine. Analgesic effect of deItatetrahydrocannabinol. Cannabis use for chronic non-cancer pain: Cannabis use in HIV for pain and other medical symptoms. Experience with the synthetic cannabinoid nabilone in chronic noncancer pain.

    Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: Cannabimimetic properties of ajulemic acid. A tale of two cannabinoids: Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

    Curr Med Res Opin. Initial experiences with medicinal extracts of cannabis for chronic pain: Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Combined cannabinoid therapy via an oromucosal spray. Cannabinoids for the treatment of pain: An update on recent clinical trials. Dexanabinol HU effect on experimental autoimmune encephalomyelitis: Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.

    Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis.

    Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice. Marihuana as a therapeutic agent for muscle spasm or spasticity. Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.

    DeltaTHC in the treatment of spasticity associated with multiple sclerosis. Adv Alcohol Subst Abuse. Nabilone in the treatment of multiple sclerosis. Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. Treatment of human spasticity with deltatetrahydrocannabinol. The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: Int J Clin Pharmacol Ther.

    Tremor in multiple sclerosis. Safety, tolerability, and efficacy of orally administered cannabinoids in MS. Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Tetrahydrocannabinol for tremor in multiple sclerosis. The effect of cannabis on tremor in patients with multiple sclerosis. Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. The effect of cannabis on urge incontinence in patients with multiple sclerosis: Curr Opin Investig Drugs.

    Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis?

    A double-blind, randomized, placebo-controlled study on patients. Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis CAMS study: Cannabinoids in multiple sclerosis CAMS study: J Neurol Neurosurg Psychiatry. From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches.

    Cannabinoids in MS - are we any closer to knowing how best to use them? The endocannabinoid pathway in Huntington's disease: Cannabinoid system and neuroinflammation: Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Neuroprotective cannabinoid receptor antagonist SRA prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra.

    Dexanabinol HU in the treatment of severe closed head injury: Efficacy and safety of dexanabinol in severe traumatic brain injury: Cannabinoid-based drugs as anti-inflammatory therapeutics. Anti-inflammatory property of the cannabinoid agonist WIN in a rodent model of chronic brain inflammation.

    Everything you need to know about CBD oil

    What are the physiological health benefits of CBD? The list .. community has relied on psychological treatments for physical pain for decades. While CBD is a component of marijuana (one of hundreds), by itself it does not cause a “high.” According to a report from the World Health. In the last few years, CBD has sparked a massive shift in the health and . a serious toll on their mental, physical, and psychological health.

    What is CBD oil?



    Comments

    uspvsglock

    What are the physiological health benefits of CBD? The list .. community has relied on psychological treatments for physical pain for decades.

    nik666

    While CBD is a component of marijuana (one of hundreds), by itself it does not cause a “high.” According to a report from the World Health.

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