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PB, EM Designed research, performed experimental procedures and produced all histological data. All authors read and approved the final manuscript. National Center for Biotechnology Information , U.
Journal List Daru v. Published online Oct Author information Article notes Copyright and License information Disclaimer. Received Jun 25; Accepted Sep This article has been cited by other articles in PMC. Conclusion All these data suggest an interesting new profile of CBD that could lead to its introduction in the clinical management of MS and its associated symptoms at least in association with current conventional therapy.
Electronic supplementary material The online version of this article doi: Ethics statement This study was carried out in strict accordance with the recommendations in the guide for the care and use of laboratory animals of the National Institutes of Health.
Indeed, at each treatment cream was spread in this area until fully absorbed, also to prevent that animals could eat or lick cream. Only after the animals were placed in their cages. The treatment was started after the onset of disease signs and then daily protracted until the sacrifice;.
Open in a separate window. Pharmacokinetic analysis Pharmacokinetc analysis of CBD plasma concentration was performed by liquid chromatography followed by mass spectrometry detection according to a reported method [ 38 ] with some modifications.
Immunohistochemical evaluation After deparaffinization with xylene, sections of spinal cord and spleen samples were hydrated.
Sections were incubated overnight with: Western blot analysis All the extraction procedures were performed on ice using ice-cold reagents. Statistical evaluation GraphPad Prism version 6. Clinical score and body weight Clinical disease score Fig. CBD enhances responsiveness to a mechanical stimulus Mice subjected to EAE show many clinical and pathological features of human MS, like paralysis of the hind limbs. CBD reduces Cleaved-caspase 3 expression induced by EAE By Western blot, we evaluated the activation of the caspase pathway, particularly, cleaved-caspase 3, which leads to programmed cell death by cleavage of cellular substrates.
Discussion Cannabis sativa represents a great source of bioactive compounds whose potential for medicinal use is currently at the center of an intense research activity, especially for the management of neurodegenerative disorders, and MS in particular. Conclusions Summarizing, we have shown that the topical administration of CBD can protect against the cascade of events inflammation, oxidative injury and neuronal cell death associated to the induction of EAE. Additional files Additional file 1: TIFF kb Additional file 2: Footnotes Sabrina Giacoppo and Maria Galuppo contributed equally to this work.
Chemical basis of hashish activity. Elsohly MA, Slade D. Chemical constituents of marijuana: Molecular characterization of a peripheral receptor for cannabinoids. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
International Union of Basic and Clinical Pharmacology. Cannabinoid receptors and their ligands: Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.
Agonistic properties of cannabidiol at 5-HT1a receptors. The peripheral cannabinoid receptor knockout mice: Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
Interaction between cytokines, cannabinoids and the nervous system. New insights into adaptive immunity in chronic neuroinflammation. Compston A, Coles A. Current treatment strategies for multiple sclerosis - efficacy versus neurological adverse effects. Cannabinoids in the management of spasticity associated with multiple sclerosis.
A cannabigerol derivative suppresses immune responses and protects mice from experimental autoimmune encephalomyelitis. Cannabinoid control of neuroinflammation related to multiple sclerosis. Kubajewska I, Constantinescu CS. Cannabinoids and experimental models of multiple sclerosis. Nasal administration of drugs as a new non-invasive strategy for efficient treatment of multiple sclerosis.
Cannabinoids in multiple sclerosis CAMS study: J Neurol Neurosurg Psychiatry. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man.
Eur J Org Chem. Analysis of cannabis seizures in NSW, Australia: Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1. Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis. Cannabinoids in experimental stroke: J Cereb Blood Flow Metab. Phytocannabinoids as novel therapeutic agents in CNS disorders. Harvey DJ, Mechoulam R. Metabolites of cannabidiol identified in human urine.
Cannabidiol bioavailability after nasal and transdermal application: Drug Dev Ind Pharm. Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. Transdermal delivery of tetrahydrocannabinol. Understanding pathogenesis and therapy of multiple sclerosis via animal models: Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease.
Mechanisms of immune injury in multiple sclerosis. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: Evidence for the production of peroxynitrite in inflammatory CNS demyelination. Cannabinoids as pharmacotherapies for neuropathic pain: The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
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