Before I wax evangelical about the benefits and wonders of CBD, THC's less fucked up, but still very cool friend, let me offer a few clear caveats. Typically, individuals switch from THC to CBD, when the intoxication associated solely with THC becomes an adverse effect. THC and CBD have very different. This case study illustrates the use of cannabidiol (CBD) oil to decrease the addictive use of marijuana and provide anxiolytic and sleep benefits. Addiction to .
to THC Switching CBD? from
Both of these substances interact with the cannabinoid receptors found in the human body and brain, but they differed dramatically in their effects. CBD is non-psychoactive which means that it will not get the user high. THC is the main psychoactive component of the cannabis plant. This compound works, in part, by mimicking the effects of anandamide and 2-AG.
These neurotransmitters are produced naturally by the human body and help to modulate sleeping and eating habits, the perception of pain, and countless other bodily functions. Research studies indicate that THC may useful in helping with: Cannabidiol is one of the most critical cannabinoids contained in the cannabis plant.
It exists both in agricultural hemp, as well as medical cannabis. While cannabinoids are present within several plants in nature, cannabis is the only plant known to contain CBD. This fact means that when you ingest CBD for medical purposes, you will more likely experience a relief of your unwanted discomfort, with little or no noticeable effect on your cognitive abilities. Research studies indicate that CBD may be useful in helping with: Research suggests CBD may be better for inflammation and neuropathic pain , while THC may excel with spasticity and cramp-related pain.
It is worth noting that sometimes high doses of THC can exacerbate pain symptoms. Meaning THC consumed in this capacity should be done in small amounts. Additionally, many individuals experience difficulty managing the side effects associated with THC, rendering useless any potential benefits. Some experts suggest that a combination of THC and CBD is the ideal way to approach pain, giving validity to something known as the entourage effect.
For example, mg of isolated CBD may be substantially less effective at alleviating symptoms than mgs of a whole-plant, CBD-containing cannabis extract. Many argue that consuming the plant in its whole form provides all the necessary cofactors to facilitate proper absorption.
This argument is at the heart of the debate over CBD oil from hemp vs. CBD oil from cannabis. While it may be cheaper and more cost-effective to extract CBD from industrial hemp, users may ultimately experience less benefit due to the absence of clinically significant levels of terpenes and other compounds which occur in abundance in high-CBD marijuana.
While high-CBD cultivars of cannabis do contain much higher levels of various cannabinoids, terpenes, etc. Agricultural hemp is much closer to the kind of cannabis that one would find growing naturally in the wild, whereas high-CBD marijuana is hybridized and toyed with by growers to produce the highest levels of the desirable compounds.
There is no hard science yet! It is up to each individual to decide which option is best for them. THC is an illegal drug with considerable immediate and long-term cognitive side effects. These include impaired thinking and reasoning, a reduced ability to plan and organize, altered decision-making, and reduced control over impulses.
Also, chronic use of THC correlates with significant abnormalities in the heart and brain. Given the increasing popularity of medical cannabis, breeders are currently creating strains with higher CBD to THC ratios to minimize the psychoactive side effects. Overall, the lower health risks of CBD, combined with its efficacy, make it a better candidate for natural applications than THC.
Your email address will not be published. Such action raises the issue of whether it might be beneficial to use CBD in isolation to facilitate withdrawal of marijuana use. The specific use of CBD for marijuana reduction has not been widely studied.
The patient was a y-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana use. With use of the CBD oil, the patient reported being less anxious, as well as settling into a regular pattern of sleep. He also indicated that he had not used any marijuana since starting the CBD oil. With the decrease in the dosage to 18 mg, the patient was able to maintain his nonuse of marijuana.
Cannabidiol CBD oil is a naturally occurring constituent of industrial hemp and marijuana collectively called cannabis. CBD oil is one of at least 85 cannabinoid compounds found in cannabis and is popular for its medicinal benefits. CBD is generally considered to be safe and has been used medicinally for decades.
The suggested medicinal effects of CBD include decreasing anxiety, improving sleep, and providing other neuroprotective effects. THC is a cannabinoid and is the component that induces the euphoric psychoactive effect. Various cannabis plants can have different amounts of CBD and THC depending on the strain, and, thus, can provide different recreational or medicinal effects. The cannabinoid profile of industrial hemp or medical marijuana is ideal for people looking for the medical benefits of CBD without the high of the THC.
The mechanism of action for CDB has been suggested to be antagonistic to the psychoactive properties of THC in many locations within the central nervous system, thus helping to attenuate the psychoactive behaviors of THC. The mechanism of action of CBD is multifold. CB 1 and CB 2 receptors. The CB 1 receptors are located mainly in the brain and modulate neurotransmitter release in a manner that 1 prevents excessive neuronal activity, thus calming and decreasing anxiety; 2 reduces pain; 3 decreases inflammation; 4 regulates movement and posture control; and 5 controls sensory perception, memory, and cognitive function.
Anandamide, an endogenous ligand that occurs naturally within our bodies, binds to the CB 1 receptors through the G-protein coupling system. CBD has an indirect effect on the CB 1 receptors by stopping the enzymatic breakdown of anandamide, allowing it to stay in the system longer and to provide its medical benefits.
The CBD helps to mediate the release of cytokines from the immune cells in a manner that helps to reduce inflammation and pain. Other mechanisms of action of CBD include stimulation of vanilloid pain receptors, such as the transient receptor potential cation channel subfamily V member 1 TRPV-1 receptor, which are known to mediate pain perception, inflammation, and body temperature.
Since the s, a considerable number of published articles have addressed the chemistry, biochemistry, pharmacology, and clinical effects of CBD. Although studies have demonstrated the calming, anti-inflammatory, and relaxing effects of CBD, clinical data demonstrating the use of CBD to obtain help in marijuana withdrawal is minimal.
One prior case study by Crippa et al 16 documented the positive effects of using CBD for the treatment of marijuana withdrawal. The current case study offers further evidence that CBD is effective as a safe method of transitioning off marijuana without unwanted side effects.
The patient was a year-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana.
His presenting concerns included erratic behaviors, anxiety, inconsistent sleep patterns, and irritability. He currently lives with his parents, works as a self-employed driver, and teaches chess to children.
Informed consent was received from the patient. Evaluations included 1 a basic, complete blood count; 2 a nutritional evaluation; 3 a comprehensive metabolic panel; 4 a lipid panel; 5 a measurement of methylene tetrahydrofolate reductase MTHFR ; 6 a celiac panel; 7 a measurement of thyroid function; 8 a measurement of iron levels; and 9 a quantitative electroencephalogram qEEG.
Dietary recommendations were then implemented as was a regimen of nutritional supplements. The patient also received neurofeedback sessions and bodywork. Prior to the period of the case study, he had been stable for a number of years. In May , it was recommended that he begin taking CBD as a way of transitioning off the daily marijuana use and stabilizing his erratic moods. The dosage was gradually decreased from 24 to 18 mg, with the patient using no sprays during the day and 6 sprays at bedtime.
CannaVest Company Las Vegas. NV, USA , which had no involvement in the case study or distribution of the product, provided the CBD oil that was administered to the patient. The PSQI is a standardized and validated self-report instrument that measures sleep quality over the prior month. Low scores indicate better sleep. A score under 5 means that you have no sleep concerns. The HAM-A scale is a standardized and validated measure of anxiety in an adult population that has been in active use for decades.
A score of 17 or less indicates mild anxiety in terms of severity. A score from 18 to 24 demonstrates mild to moderate anxiety severity.
Last, a score of 25 to 30 indicates moderate to severe anxiety. Using the CBD oil, the patient was able to maintain nonuse of marijuana. With a subsequent, gradual decrease in anxiety, the patient was able to maintain a regular sleeping schedule Table 2. He was able to get a more secure job as a self-employed driver, and he continued to teach chess to children.
He also became more interactive with his family and friends. The current case study found that CBD oil can be an effective compound to use for transitioning an individual off addictive use of marijuana.
However, the patient made significant gains in taking responsible actions and presented fewer erratic and disorganized behaviors. A systematic review of the literature previously had examined 14 studies on the use of CBD oil to modulate various neuronal circuits involved in drug addiction.
One reported consequence of the cessation of daily marijuana use is a withdrawal syndrome that is characterized by irritability, anxiety, marijuana craving, decreased quality and quantity of sleep, and reduced food intake. The patient reported being less anxious and sleeping better since taking the CBD oil. He reported not using any marijuana since starting the CBD and was proud of his accomplishment of getting a job as a self-employed driver and continuing with teaching chess to children.
The author participated in no competing interests that would have affected the results of the case study. No financial support was provided by CannaVest at any time. National Center for Biotechnology Information , U.
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Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report
The past year has seen a surge of interest in marijuana's CBD, a non-intoxicating cannabis compound with significant therapeutic properties. As the legal use of marijuana and other cannabis products grows, consumers are becoming more curious about their options. This includes cannabidiol (CBD). Why are people so excited about Cannabidiol (CBD)? Why are growers breeding marijuana plants with significantly higher levels of CBD? The answer lies in.