Click this link to Read the Rules. Want to help out? Click here to apply to be a moderator. And remember the golden rule of /r/skeptic. A study of high-dose CBD (1, mg per day) among adults with Most products contained very small concentrations of CBD — similar to what is . Can hemp oil or CBD (cannabidiol) supplements cause me to fail a drug test? >> . Is it either ignorance of how to process the material or outright fraud?. Unlike THC, CBD can be administered at relatively high doses An odd distinction existed from until where what you is formula (1) wherein the R group is independently selected from the Let's be very clear.
Do Does r/skeptic Really - Anything? CBD
Tranquilizers, antidepressants and ED medicines are all intended to make us feel emotionally better, even euphoric. While some may not want the euphoria associated with THC and other euphorogenic constituents of the plant, there is the therapeutic consideration of the benefit of using the whole plant the entourage effect. As with any therapeutic agent the physician will weigh the balance of the therapeutic effects to the side effects.
Many clinicians believe that using CBD as an isolated compound not only diminishes its therapeutic value but does not take full advantage of the medicinal value of cannabis. This is because of the entourage effect, the concept that the totality of the therapeutic constituents of the plant acting together are more effective than any single isolated compound acting alone.
Cannabis contains several hundred compounds, including various flavonoids, aromatic terpenes, and many minor cannabinoids in addition to THC and CBD. When looking at the effects of cannabis we need to be cognizant that different routes of cannabinoid administration have different effects. Inhaled THC enters capillaries in the lungs, passes into general circulation through the pulmonary arteries and goes directly to the brain without passing through the liver.
The cannabinoids then cross the blood-brain barrier to affect the endocannabinoid receptors. In addition, when cannabis is burned new compounds are created not found in the raw or dried plant. The respiratory route of administration allows THC and other constituents of the plant to go directly to the brain without going through the liver. THC metabolites contribute significantly to the effects of cannabis consumption.
It induces a high more potently than THC itself. When ingested orally, however, THC and other cannabinoids and terpenes are absorbed from the small intestine over several hours.
Like any oral medication, it will take about minutes before enough of the plant constituents are in the bloodstream to exert a therapeutic effect.
All plants are chemically complex, containing hundreds of different molecules. A tomato has about different molecules. Of these compounds, are cannabinoids and over are terpenes. Many of these chemicals have therapeutic value. The ECS is the largest neurotransmitter system in the brain. It can be affected by both exogenous from outside the body and endogenous from inside the body cannabinoids that exert their many pharmacological effects.
There are at least two types of cannabinoid receptors in mammalian tissues, dubbed CB1 and CB2 receptors. CB1 receptors are not only in the brain and spinal cord but in peripheral tissues as well. CB2 receptors are found primarily in immune tissues. It is quite likely that in the near future, research will identify more components of the ECS. He focused on a young child who had intractable seizures. Several years earlier, Dr. Mechoulam described an experiment by Paul F.
Consroe and colleagues in Brazil where CBD was tested as a treatment for intractable epilepsy. The subjects were followed over the course of several months. Mechoulam noted that of the seven patients getting CBD; three became seizure-free; one experienced only one or two seizures; and two experienced reduced severity and occurrence of seizures.
Only one showed no improvement. CBD is one of the reasons that cannabis has been known for centuries as an anti-seizure medicine. Now in the second decade of the twenty-first century, there is increased public interest in this therapeutic property of cannabis. As a side note, earlier this year Brazil approved the use of CBD to treat epilepsy. Prescribing is restricted to psychiatrists and neurologists. After using hemp oil, he says, his headaches went away, the ringing in his ears got tolerable, he slept better, and his arthritis disappeared.
The oil controlled the pain, my blood pressure, and it allowed me to sleep. I lost weight and looked 20 years younger. Anyway, in Simpson had one facial spot removed and biopsied. Before he got the results of the biopsy, he self-diagnosed himself as having an infection where the spot had been removed. He applied cannabis oil to two other spots that hadn't been surgically removed and a few days later, he says, they were gone.
He put the oil on his self-diagnosed infection and it too disappeared. He self-diagnosed that the cancer came back and again he applied cannabis and again he concluded that cannabis had cured his cancer.
The biopsy had confirmed, he says, that the removed spot was basal cell skin cancer. The other two spots weren't tested before they disappeared. Simpson seems to have concluded that since the spot removed was skin cancer, the other two spots were also cancerous. His doctor, of course, rejected Simpson's belief that he had cured his own cancer with hemp oil. Simpson couldn't understand why the doctor didn't believe him.
He had this personal experience that proved what he claimed, didn't he? Why wouldn't the doctor admit that removing the skin cancer wasn't what cured him, that it was the rubbing on of hemp oil that cured him? Furthermore, after he used his hemp oil to cure many people of many different ailments, including his mother's psoriasis, he could not understand why neither the medical experts nor those in law enforcement didn't get it.
He had his own personal experience with the cure and he now had the testimonials from many others to back him up. He had cured cancers, diabetes, arthritis, glaucoma, and other diseases. What more did these people want by way of proof? No one should doubt Simpson's sincerity. He passionately believes in the medicinal virtues of hemp oil. He grew his own plants and made his own oil.
He gave away his oil to those in need until the police took out his marijuana plants and he had to buy his pot to make his oil. Even now , when he is somewhat of a minor celebrity giving seminars in Europe and author of a book, he does not come across as being in it for the money or the fame.
Rick's son, Mike, however, is taking donations by PayPal, credit card, check, or cash. Scroll to the bottom of any page on http: Rick Simpson may be a brilliant man and I don't think we should hold it against him that he has no medical background or that his education stopped in the 9th grade.
But, like many brilliant men, Simpson did not try to back up his personal experience with scientific evidence. He did what most of do most of the time: His reasoning followed his natural instincts. It is unnatural to do what scientists do: To him, his belief that cannabis cures cancer was a matter of common sense. It would have seemed weird to him to act as if his belief that cannabis cures cancer were a hypothesis to be tested.
What would we expect him to do, give fake hemp oil to some of his friends to see if there was some sort of placebo effect going on? Scientists and experts in cognitive biases know that confirmation bias added to wishful thinking is a recipe for self-deception. Rick Simpson is not a scientist. He's a non-scientist who followed his instincts and drew conclusions that seemed obviously true to him and his fellow believers.
Before concluding this article with a review of what the scientific evidence shows regarding cannabis and cancer, I recommend the reader take a look at several essays and a book I've written about the problems that can occur when we blindly follow our natural instincts.
Our natural way of thinking works well enough for many matters in daily life, but it is not very reliable when it comes to evaluating complex causal events such as what causes or cures cancer. For that we need well-designed tests that will minimize our natural biases and lessen our chances of self-deception. Collecting anecdotes, which is what Simpson has done , is important but it is not a substitute for controlled studies on humans. One simple and obvious problem with Simpson's method of establishing his claims about hemp oil is that he seems oblivious to the need to isolate the chemical compounds that might be having a medicinal effect.
He also seems oblivious to the need for quality control to establish dosage. He mixes what he grows or buys without scientific analysis of how much THC or any other chemical, for example, he is dealing with. He's eyeballing everything and has no idea what dose he is giving to anybody. The dosage of any medicine is absolutely essential to determining its effectiveness and safety.
Nor does he keep records. A scientist would note when, where on the body, and how much hemp oil was ingested or applied. Meticulous records would be kept as to how long the treatment went on, what other treatments were given in conjunction to the hemp oil, etc.
Otherwise, in the end all you have is a bunch of stories that are of little value to the issue of whether there is a causal connection between hemp oil and any kind of palliative effect.
Also, Simpson knows that not everyone using hemp oil is cured. He and his advocates, like the folks at High Times , explain the failures, but their explanations sound like rationalizations:.
Unfortunately, not everyone is saved by the oil. While the HT photographer was taking pictures for this story, Simpson received word that one of his patients had died after only two days of treatment. Simpson provides no evidence for his claimed success rate. Nor does HT provide any evidence for its claims that cancer patients die more frequently from chemotherapy than from cancer and that Big Pharma is preventing the world from enjoying a cheap cure for just about anything that ails anyone.
In their fantasy world, Simpson and his advocates seem to think they can just make stuff up as it suits them. There are several people who have investigated the scientific evidence for the claim that cannabis cures cancer. David Gorski, a breast cancer specialist, examines Arjun Walia's web page: From what we know now, it is quite clear that cannabis does not cure cancer, at least not by itself and certainly not ingested or smoked as marijuana or ingested or applied topically as hemp oil.
Even in purified form, naturally-derived or synthetic cannabinoid agonists show relatively modest antitumor activity in preclinical models, which means that they will have to be combined with existing chemotherapeutic regimens. If they do find their way into the routine clinical treatment of cancer, it will be through rigorous pharmacological studies and rigorous clinical trials, the latter of which, in particular, are painfully lacking.
CancerResearchUK has also investigated the studies cited to support the notion that cannabis cures cancer. There is no doubt that cannabinoids — both natural and synthetic — are interesting biological molecules. Guess what CancerResearchUK found when they investigated these scientific papers? Does the lack of strong clinical evidence that cannabis cures cancer mean that there is no possible benefit from cannabis for those of us with cancer? Many people use marijuana to prevent nausea, anorexia, and vomiting.
There are, however, some safer, cheaper drugs that work quite well for these problems. I've found Zofran ondansetron has helped me enormously. That said, I have applied for a marijuana card and will use cannabis if the Zofran quits working. I may even try cannabis to help me sleep. I don't have any significant pain right now, so I won't be trying cannabis for pain relief.
I tried cannabis oil and some tablets for a couple of months but quit. It was expensive, did help me sleep better but my ocean wave sound machine seems more effective. I also didn't like the fact that I had no idea how pure the stuff was or whether the doses I was taking would do more good than harm.
Studies are ongoing and someday there may be strong clinical evidence cannabis is not only beneficial for alleviating some of the more irritating side effects of cancer and cancer-treatments, but for treatment of some cancers themselves. But for now, the claims for the miraculous healing powers of cannabis are highly exaggerated and based more on wishful thinking and self-deception than on solid evidence.
See also natural cancer cures. However, normal cells were not affected this way, showing yet again that cannabinoids can selectively target abnormal cells while leaving healthy tissue alone.
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases.
Overall, the cannabinoids affect multiple cellular signaling pathways, which means they have the potential to decrease cancer development, growth, and metastasis. However, there are likely to be both cancer- and cannabinoid-specific elements to these effects
The rise of the cannabis cult: don’t believe the hype about medical marijuana
CBD Oil can help fight cancer and IBS, improve schizophrenia symptoms, CBD is a very promising remedy for a variety of inflammatory and was something scientists had no clue a couple decades ago [R]. .. Just got my organic locally grown CBD OIL ~ lm alttle skeptic to try CBD oil for my ALziemers. “We're talking about something that could really help people.” “About 3 weeks ago I started taking CBD-oil 10 percent and I can't even describe . Skeptics who assume CBD is just 21st-century snake oil, however, may be. As marijuana is legalized in more and more states, the wellness world has whipped itself into a frenzy over a non-intoxicating cannabis.