Cannabidiol, or CBD, is a chemical compound in marijuana with a variety of uses . Tetrahydrocannabinol (THC) is the main psychoactive cannabinoid . Before you start using CBD oil, discuss it with your doctor to ensure. Everything you need to know about CBD oil People take or apply cannabidiol to treat a variety of symptoms, but its use is controversial. This means that CBD does not change a person's state of mind when they use it. This is the potential use for CBD with the most evidence after "There's no control, so it's basically how do you know if we're dealing with the.
CBD do does you? What to
Products containing the compound are now legal in many American states where marijuana is not. This article will explain what CBD is, its possible health benefits, how to use it, potential risks, and issues surrounding its legality in the United States. CBD is one of many compounds, known as cannabinoids, in the cannabis plant. Researchers have been looking at the possible therapeutic uses of CBD. The concentrations and the uses of these oils vary.
THC creates a mind-altering "high" when a person smokes it or uses it in cooking. This is because THC breaks down when we apply heat and introduce it into the body. Unlike THC, it is not psychoactive. This means that CBD does not change a person's state of mind when they use it. However, CBD does appear to produce significant changes in the body, and some research suggests that it has medical benefits.
The least processed form of the cannabis plant is hemp. Hemp contains most of the CBD that people use medicinally. Hemp and marijuana come from the same plant, Cannabis sativa , but the two are very different. Over the years, marijuana farmers have selectively bred their plants to contain high levels of THC and other compounds that interested them, often because the compounds produced a smell or had another effect on the plant's flowers. However, hemp farmers have rarely modified the plant.
These hemp plants are used to create CBD oil. The human body produces certain cannabinoids on its own. It also has two receptors for cannabinoids, called the CB1 receptors and CB2 receptors.
The CB1 receptors in the brain deal with coordination and movement, pain, emotions, and mood, thinking, appetite, and memories, and other functions. THC attaches to these receptors. CB2 receptors are more common in the immune system. They affect inflammation and pain. People tend to use prescription or over-the-counter drugs to relieve stiffness and pain, including chronic pain.
Authors of a study published in the Journal of Experimental Medicine found that CBD significantly reduced chronic inflammation and pain in some mice and rats. The researchers suggested that the non-psychoactive compounds in marijuana, such as CBD, could provide a new treatment for chronic pain. Some promising evidence suggests that CBD use may help people to quit smoking.
A pilot study published in Addictive Behaviors found that smokers who used inhalers containing CBD smoked fewer cigarettes than usual and had no further cravings for nicotine. A similar review, published in Neurotherapeutics found that CBD may be a promising treatment for people with opioid addiction disorders.
The researchers noted that CBD reduced some symptoms associated with substance use disorders. These included anxiety , mood-related symptoms, pain, and insomnia. More research is necessary, but these findings suggest that CBD may help to prevent or reduce withdrawal symptoms. After researching the safety and effectiveness of CBD oil for treating epilepsy, the FDA approved the use of CBD Epidiolex as a therapy for two rare conditions characterized by epileptic seizures in The types of seizures that characterize LGS or DS are difficult to control with other types of medication.
The FDA specified that doctors could not prescribe Epidiolex for children younger than 2 years. A physician or pharmacist will determine the right dosage based on body weight. Authors of a review noted that CBD has anti-seizure properties and a low risk of side effects for people with epilepsy. Findings suggested that CBD may also treat many complications linked to epilepsy, such as neurodegeneration, neuronal injury, and psychiatric diseases. Another study, published in Current Pharmaceutical Design, found that CBD may produce effects similar to those of certain antipsychotic drugs, and that the compound may provide a safe and effective treatment for people with schizophrenia.
However, further research is necessary. Some researchers have found that CBD may prove to combat cancer. Authors of a review published in the British Journal of Clinical Pharmacology found evidence that CBD significantly helped to prevent the spread of cancer. The researchers also noted that the compound tends to suppress the growth of cancer cells and promote their destruction.
They pointed out that CBD has low levels of toxicity. They called for further research into its potential as an accompaniment to standard cancer treatments. Doctors often advise people with chronic anxiety to avoid cannabis, as THC can trigger or amplify feelings of anxiousness and paranoia. However, authors of a review from Neurotherapeutics found that CBD may help to reduce anxiety in people with certain related disorders.
According to the review, CBD may reduce anxiety-related behaviors in people with conditions such as:. The authors noted that current treatments for these disorders can lead to additional symptoms and side effects, which can cause some people to stop taking them.
No further definitive evidence currently links CBD to adverse effects, and the authors called for further studies of the compound as a treatment for anxiety. Type 1 diabetes results from inflammation that occurs when the immune system attacks cells in the pancreas. Research published in by Clinical Hemorheology and Microcirculation found that CBD may ease this inflammation in the pancreas. This may be the first step in finding a CBD-based treatment for type 1 diabetes.
A paper presented in the same year in Lisbon, Portugal, suggested that CBD may reduce inflammation and protect against or delay the development of type 1 diabetes. Acne treatment is another promising use for CBD. The condition is caused, in part, by inflammation and overworked sebaceous glands in the body. A study published by the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body.
Sebum is an oily substance, and overproduction can cause acne. Initial research published in the Journal of Alzheimer's Disease found that CBD was able to prevent the development of social recognition deficit in participants. This means that CBD could help people in the early stages of Alzheimer's to keep the ability to recognize the faces of people that they know. This is the first evidence that CBD may slow the progression of Alzheimer's disease. Cannabis is legal for either medicinal or recreational use in some American states.
Other states have approved the use of CBD oil as a hemp product but not the general use of medical marijuana. Some state and federal laws differ, and current marijuana and CBD legislation in the U. There is an ever-changing number of states that do not necessarily consider marijuana to be legal but have laws directly related to CBD oil.
The following information is accurate as of May 8, , but the laws change frequently. However, state legislators generally approve the use of CBD oil at various concentrations to treat a range of epileptic conditions. A full list of states that have CBD-specific laws is available here. Different states also require different levels of prescription to possess and use CBD oil.
In Missouri, for example, a person can use CBD of a particular composition if they can show that three other treatment options have failed to treat their epilepsy. Anyone considering CBD oil should speak with a local healthcare provider.
They can provide information about safe CBD sources and local laws surrounding usage. This is one of more than 80 active chemicals in marijuana. The new product was approved to treat seizures associated with two rare, severe forms of epilepsy in patients two years of age and older. Many small-scale studies have looked into the safety of CBD in adults. They concluded that adults tend to tolerate a wide range of doses well. Researchers have found no significant side effects on the central nervous system , the vital signs, or mood, even among people who used high dosages.
The most common side effect was tiredness. Also, some people reported diarrhea and changes in appetite or weight.
Concerning the product that the FDA approved to treat two types of epilepsy, researchers noticed following adverse effects in clinical trials:. The patient information leaflet notes that there is a risk of worsening depression or suicidal thoughts.
It is important to monitor anyone who is using this drug for signs of mood change. Research suggests that a person taking the product is unlikely to form a dependency. There is often a lack of evidence regarding the safety of new or alternative treatment options. Usually, researchers have not performed the full array of tests.
Anyone who is considering using CBD should talk to a qualified healthcare practitioner beforehand. When drugs do not have FDA approval, it can be difficult to know whether a product contains a safe or effective level of CBD.
Unapproved products may not have the properties or contents stated on the packaging. It is important to note that researchers have linked marijuana use during pregnancy to impairments in the fetal development of neurons. Regular use among teens is associated with issues concerning memory, behavior, and intelligence. CBD-based products come in many forms. Some can be mixed into different foods or drinks or taken with a pipette or dropper. Others are available in capsules or as a thick paste to be massaged into the skin.
CBD is an allosteric modulator at several receptor sites in our bodies. Allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors.
This means it enhances the ability of these receptors to receive endogenous enkephalins which can increase quality of life and naturally reduce pain. At high doses , CBD activates the 5-ht1A receptor. The 5-ht1A receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. GPR55 receptors are widely distributed in the brain especially the cerebellum and help to control bone density and blood pressure.
When activated, GPR55 promotes cancer cell proliferation. This antagonizing action may help explain the natural value of supplementing with CBD in individuals with cancer, osteoporosis, and high blood pressure. TRPV1 is involved in regulating pain, body temperature, and inflammation. Clinical Endocannabinoid Deficiency is a condition where an individual has a lower amount of endogenous cannabinoids than is considered necessary to promote health and well-being.
Scientists now believe CECD may play a role in the following conditions: Many of these conditions are treated with a range of medications that carry some heavy side effects.
As the research develops, if CECD is found to be the culprit behind these conditions, CBD would help increase endocannabinoids in the body without many of the risks associated with pharmaceuticals. In other words, it is the sum of its parts that make cannabis so effective. For example, mg of isolated CBD may be substantially less effective at alleviating symptoms than mg of a whole-plant, cannabis extract. Vitamin C may be a good analogy.
Many vitamin C supplements are presented in the form of ascorbic acid. Ascorbic acid is just one of the many compounds that comprise the whole vitamin C. In fact, in all of his years of research, the discoverer of Vitamin C and Nobel prize laureate Dr. Albert Szent-Georgi was never able to cure scurvy with isolated ascorbic acid. In contrast, eating an orange provides whole vitamin C with all the necessary cofactors for optimum absorption. It is this very concept that lies at the center of the CBD oil from hemp vs.
CBD oil from cannabis debate. While it may be cheaper and more cost-effective to extract CBD from industrial hemp, users may ultimately experience fewer benefits due to the absence of clinically significant levels of terpenes and other compounds which occur in abundance in high-CBD cannabis. Agricultural hemp is much closer to the kind of cannabis that one would find growing naturally, whereas high-CBD cannabis is hybridized and altered by growers to produce the highest levels of the desired compounds.
Unfortunately, there are no hard facts about the validity of the entourage effect. It is up to each individual to research, consult with medical professionals, and decide for themselves the best path forward. Research suggests CBD may be better for inflammation and neuropathic pain , while THC may excel with spasticity and cramp-related pain. High doses of THC can exacerbate current pain symptoms making micro-dosing with THC a more reasonable pain management strategy.
THC is illegal and carries considerable immediate and long-term cognitive side effects. These include impaired thinking and reasoning, a reduced ability to plan and organize, altered decision-making, and reduced control over impulses. In addition, chronic use of THC correlates with significant abnormalities in the heart and brain. CBD lacks many of these harmful effects.
Everything you need to know about CBD oil
However, cannabis contains many other cannabinoids – most of which do not get you high, like CBD. Some cannabis plants are bred for high CBD content. Can cannabis keep you healthy? Get the facts on CBD oil, a natural product that may ease your anxiety and boost your heart health. CBD, or cannabidiol, is non-intoxicating and does not cause the noticeable . It is also easy to overconsume CBD oil, so it's important to start with a low dose, as it may take several hours or. One editor explains how she took CBD oil every day for a week to help her anxiety. CBD does not produce the psychoactive effects that make you feel placed on hospice care and given a "do not resuscitate" order when.